18-2-1 Artículos internacionales

Artículos y capítulos de libros en revistas y libros internacionales

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A-2. Meléndez, E. & Municio, A. M. (1972) Studies on the control of lactate dehydrogenase isoenzyme activity from rat brain by NAD+. International Journal of Biochemistry, 3, 437-442.

A-3. Meléndez, E. & Municio, A. M. (1972) Studies on the control of lactate dehydrogenase isoenzyme activity from rat striated muscle by NAD+. International Journal of Biochemistry, 3, 482-486.

A-4. Acebal, C., Castro, J., Meléndez, E. & Municio, A. M. (1974) Metabolic influences on the lactate dehydrogenase isoenzyme patterns in several rabbit tissues. International Journal of Biochemistry, 5, 23-29.

A-7. González de Buitrago, J. M., Meléndez-Hevia, E. & Municio, A. M. (1981) Shift in vivo in the lactate dehydrogenase isoenzyme pattern in experimental models conditioning the metabolic adaptation of rat brain. International Journal of Biochemistry, 13, 1119-1121.

A-8. Meléndez-Hevia, E., Corzo, J. & Pérez, J. (1981) Electrophoretic and stain method for pyruvate kinase isoenzyme patterns. En: Electrophoresis´81 (Allen, R. C. & Arnaud, Ph., eds). Walter de Gruyter & Co., Berlin, pp. 693-698.

A-9. González Lama, Z., de Armas, A., Betancor, P. & Meléndez-Hevia, E. (1981) Isoenzymes of superoxide dismutase in liver from Lacerta stehlini. En: Electrophoresis´81 (Allen, R. C. & Arnaud, Ph., eds). Walter de Gruyter & Co., Berlin, pp. 703-707.

A-10. Pérez, J. A., Siverio, J. M., Corzo, J. & Meléndez-Hevia, E. (1982) Cooperative ATP inhibition and fructose 1,6-biphosphate activation of rat liver pyruvate kinase. International Journal of Biochemistry, 14, 63-66.

A-11. Pérez, J. A., Mateo, F. & Meléndez-Hevia, E. (1982) Nucleotide isotachophoretic assay: Method and application for determination of ATP/ADP ratio in several rat tissues. Electrophoresis, 3, 102-106.

A-12. González-Lama, Z., Cutillas, M. J., Lamas, A. M. & Meléndez-Hevia, E. (1983) Polyacrylamid-starch gel electrofocusing of catalase from Pseudomonas aeruginosa. En: Electrophoresis´82, Walter de Gruyter & Co., Berlin, pp. 481-484.

A-13. Torres, N. V., Sánchez, L. D., Pérez, J. A. & Meléndez-Hevia, E. (1984) Regulation of glycolysis in lizards: kinetic studies on liver pyruvate kinase and phosphofructokinase of Lacerta galloti. Comparative Biochemistry and Physiology, 77B, 289-294.

A-14. Corzo, J., Riol-Cimas, J. M. & Meléndez-Hevia, E. (1984) Fish species identification by electrophoresis of muscle proteins in sodium dodecyl sulfate-containing polyacrylamide slab gels. Electrophoresis, 5, 168-170.

A-15. Meléndez-Hevia, E., Siverio, J. M. & Pérez, J. A. (1984) Studies on glycolysis in vitro: Role of glucose phosphorylation and phosphofructokinase activity on total velocity. International Journal of Biochemistry, 16, 469-476.

A-16. Siverio, J. M., Torres, N. V. & Meléndez-Hevia, E. (1985) Activities of l-lactate and glycerol phosphate production rates in vitro from glucose 6-phosphate in regenerating rat liver. International Journal of Biochemistry, 17, 1015-1017.

A-17. Meléndez-Hevia, E. & Isidoro, A. (1985) The game of the pentose phosphate cycle. Journal of Theoretical Biology, 117, 251-263.

A-19. Torres, N. V., Mateo, F., Meléndez-Hevia, E. & Kacser, H. (1986) Kinetics of metabolic pathways. A system in vitro to study the control of flux. Biochemical Journal, 234, 169-174.

A-20. Riol-Cimas, J. M. & Meléndez-Hevia, E. (1986) Distribution of metabolic fluxes towards glycerol phosphate and L-lactate from fructose 1,6-biphosphate in vitro: effect of glycerol phosphate dehydrogenase. International Journal of Biochemistry, 18, 853-856.

A-22. Riol-Cimas, J. M. & Meléndez-Hevia, E. (1988). Kinetics of metabolic pathways. Transient response of the glycolytic system after phosphofructokinase reaction to ADP input. International Journal of Biochemistry, 20, 29-33.

A-23. Torres, N. V., Mateo, F., Sicilia, J. & Meléndez-Hevia, E. (1988) Distribution of the flux control in convergent metabolic pathways: Theory and application to experimental and simulated systems. International Journal of Biochemistry, 20, 161-165.

A-24. García-Tejedor, A., Riol-Cimas, J. M., Morán, F., Meléndez-Hevia, E. & Montero, F. (1988) Transition state of the glycolytic pathway under FDP saturating conditions: experimental studies and a theoretical model. International Journal of Biochemistry, 20, 421-426.

A-25. Torres, N. V., Mateo, F. & Meléndez-Hevia, E. (1988) Shift in rat liver glycolysis control from fed to starved conditions: flux control coefficients of glucokinase and phosphofructokinase. FEBS Letters, 233, 83-86.

A-26. Meléndez-Hevia, E. & Torres, N. V. (1988) Economy of the design in metabolic pathways. Further remarks on the game of the pentose phosphate cycle. Journal of Theoretical Biology, 132, 97-111.

A-27. Torres, N. V., Meléndez-Hevia, E. & Riol-Cimas, J. M. (1988) A study of the distribution of flux control coefficients in an in vitro metabolic system: a practical exercise. Biochemical Education, 16, 100-102.

A-28. Mateo, F., Torres, N. V. & Meléndez-Hevia, E. (1989) Role of hexokinase in controlling the glucose metabolism flux: a study of its flux control coefficient in different tissues. Cellular and Molecular Biology, 35, 33-37.

A-29. Torres, N. V., Souto, R. & Meléndez-Hevia, E. (1989) Study of the flux and transition time control coefficient profiles in a metabolic system in vitro, and the effect of an external stimulator. Biochemical Journal, 260, 763-769.

A-30. Torres, N. V., Meléndez-Hevia, E. & Riol-Cimas, J. M. (1989) A study of the distribution of flux control coefficients in an in vitro metabolic system. En: Practical Biochemistry for Colleges (Wood, E. J., ed). Pergamon Press, Oxford, pp. 107-108.

A-31. Meléndez-Hevia, E., Torres, N. V., Sicilia, J. & Kacser, H. (1990) Control analysis of transition times in metabolic systems. Biochemical Journal, 265, 195-202.

A-32. Torres, N. V., Mateo, F., Riol-Cimas, J. M. & Meléndez-Hevia, E. (1990) Control of glycolysis in rat liver by glucokinase and phosphofructokinase: influence of glucose concentration. Molecular and Cellular Biochemistry, 93, 21-26.

A-33. Meléndez-Hevia, E., Torres, N. V. & Sicilia, J. (1990) A generalization of metabolic control analysis to conditions of no proportionality between activity and concentration of enzymes. Journal of Theoretical Biology, 142, 443-451.

A-34. Meléndez-Hevia, E. (1990) The game of the pentose phosphate cycle. A mathematical approach to study the optimization in design of metabolic pathways during evolution. Biomedica et Biochimica Acta, 49, 903-916.

A-35. Meléndez-Hevia, E. & Torres, N. V. (1990) Determination of flux control coefficients by shortening and enzyme titration of metabolic pathways. En: Control of metabolic processes (Cornish-Bowden, A. & Cárdenas, M. L., eds). Plenum Press, New York, pp. 231-238.

A-39. Torres, N. V. & Meléndez-Hevia, E. (1991) Detailed protocol and critical view for the analysis of control in metabolic systems by shortening and enzyme titration. Molecular and Cellular Biochemistry, 101, 1-10.

A-40. Cascante, M., Torres, N. V, Franco, R., Meléndez-Hevia, E. & Canela, E. I. (1991) Control analysis of transition times. Extension of analysis and matrix method. Molecular and Cellular Biochemistry, 101, 83-91.

A-41. Torres, N. V., Sicilia, J. & Meléndez-Hevia, E. (1991) Analysis and characterization of transition states in metabolic systems. Transition times and the passivity of the output flux. Biochemical Journal, 276, 231-236.

A-42. Meléndez-Hevia, E. & Montero, F. (1991) Channelling and evolution of metabolism. Journal of Theoretical Biology, 152, 77-79.

A-43. Torres, N. V. & Meléndez-Hevia, E. (1992) Transition time control analysis of a glycolytic system under different glucose concentrations. Control of transition time versus control of flux. Molecular and Cellular Biochemistry, 112, 109-115.

A-44. Meléndez-Hevia, E., Mateo, F. & Torres, N. V. (1992) Control analysis of rat liver glycolysis under different glucose concentrations. The substrate approach and the role of glucokinase. Molecular and Cellular Biochemistry, 115, 1-9.

A-46. Meléndez-Hevia, E., Waddell, T. G. & Shelton, E. (1993) Optimization of molecular design in the evolution of metabolism. The glycogen molecule. Biochemical Journal, 295, 477-483.

A-47. Meléndez-Hevia, E., Waddell, T. G. & Montero, F. (1994) Optimization of metabolism: The evolution of metabolic pathways toward simplicity through the game of the pentose phosphate cycle. Journal of Theoretical Biology, 166, 201-220.

A-48. Meléndez-Hevia, E. (1994) Physiological optimization of metabolism: An evolutionary approach. Pflugers Archiv European Journal of Physiology, 427, suppl. No.1, R1.

A-49. Raposo, R. R., Boluda, C., Cabezas, H. & Meléndez-Hevia, E. (1994) Pentose phosphate cycle in rat tissues. A new method for assaying the whole pathway activity. Pflugers Archiv European Journal of Physiology, 427, suppl. No.1, R31.

A-50. Meléndez-Hevia, E., Waddell, T. G., Raposo, R. R. & Lupiáñez, J. A. (1995) Evolution of metabolism: Optimization of glycogen structure. Journal of Biological Systems, 3, 177-186.

A-51. Cascante, M., Meléndez-Hevia, E., Kholodenko, B., Sicilia, J. & Kacser, H. (1995) Control analysis of transit time for free and enzyme-bound metabolites: Physiological and evolutionary significance of metabolic response times. Biochemical Journal, 308, 895-899.

A-54. Meléndez-Hevia, E., Waddell, T. G. & Montero, F. (1996) Selection of enzymatic mechanisms which account for simplicity in the evolution of metabolic pathways. En: World Congress of Nonlinear Analysts ‘92 (Lakshmikantham, V., ed). Walter de Gruyter, Berlin, New York, Vol. 2, pp. 3291-3304.

A-55. Meléndez-Hevia, E., Waddell, T. G. & Sicilia, J. (1996) Optimization of glycogen design in the evolution of metabolism. En: Biomedical and life physics (Ghista, D. N., ed.) Vieweg, Munchen, pp. 49-59.

A-56. Montero, F., Nuño, J. C., Andrade, M. A., Pérez-Iratxeta, C., Morán, F. & Meléndez-Hevia, E. (1996). The role of natural selection and evolution in the game of the pentose phosphate cycle. En: Biomedical and life physics (Ghista, D. N., ed.). Vieweg, Munchen, pp. 155-168.

A-57. Lupiáñez, J. A., García-Salguero, L., Torres, N. V., Peragón, J. & Meléndez-Hevia, E. (1996) Metabolic support of the flight promptness of birds. Comparative Biochemistry and Phsiology, 113B, 439-443.

A-58. Meléndez-Hevia, E., Waddell, T. G. & Cascante, M. (1996) The puzzle of the Krebs citric acid cycle: assembling the pieces of chemically feasible reactions, and opportunism in the design of metabolic pathways during evolution. Journal of Molecular Evolution, 43, 293-303.

A-59. Acerenza, L., Cárdenas, M. L., Cascante, M., Hofmeyr, J., Meléndez-Hevia, E., Ovádi, J., Quant, P. A., Small, R. & Szedlacsel, S. (1996) Personal glimpses of Henrik Kacser (1918-1995). Journal of Theoretical Biology, 182, 201-207.

A-60. Cascante, M., Lloréns, M., Meléndez-Hevia, E., Puigjaner,J., Montero, F. & Martí, E. (1996) The metabolic production of the cell factory. Journal of Theoretical Biology 182, 317-325.

A-61. Meléndez-Hevia, E., Sicilia, J., Ramos, M. T., Canela, E. I. & Cascante, M. (1996) Molecular bureaucracy. Who controls the delays? Transient times in branched pathways, and their control. Journal of Theoretical Biology 182, 333-339.

A-63. Heinrich, R., Montero, F., Klipp, E., Waddell, T. G. & Meléndez-Hevia, E. (1997) Theoretical approaches to the evolutionary optimization of glycolysis. Thermodynamic and kinetic constraints. European Journal of Biochemistry, 243, 191-201.

A-64. Meléndez-Hevia, E., Waddell, T. G., Heinrich, R. & Montero, F. (1997) Theoretical approaches to the evolutionary optimization of glycolysis. Chemical analysis. European Journal of Biochemistry, 244, 527-543.

A-65. Nuño, J. C., Sánchez-Valdenebro, I., Pérez-Iratxeta, C., Meléndez-Hevia, E., & Montero,F. (1997). Network organization of cell metabolism: monosaccharide interconversion. Biochemical Journal 324, 103-111.

A-66. Meléndez, R., Meléndez-Hevia, E., & Cascante, M. (1997) How did glycogen structure evolve to satisfy the requirement for rapid mobilization of glucose? A problem of physical constraints in structure building. Journal of Molecular Evolution 45, 446-455.

A-67. Heinrich, R., Montero, F., Klipp, E., Waddell, T. G. & Meléndez-Hevia, E. (1997) Kinetic and thermodynamic constraints for the structural design of glycolysis. Nonlinear analysis: Theory, methods and applications. 30, 1793-1804.

A-68. Montero, F., Nuño, J. C., Sánchez-Valdenebro, I., Pérez-Iratxeta, C., & Meléndez-Hevia, E. (1997) Stoichiometric properties of the non-oxidative phase of the pentose phosphate cycle. Nonlinear analysis. Theory, methods and applications. 30, 1865-1874.

A-70. Waddell, T. G., Repovic, P., Meléndez-Hevia, E., Heinrich, R. & Montero, F. (1997) Optimization of glycolysis: a new look at the efficiency of energy coupling. Biochemical Education, 25, 204-205.

A-71. Meléndez-Hevia, E., Guinovart, J. J. & Cascante, M. (1997) The role of channelling in glycogen metabolism. En: Channelling in intermediary metabolism (Agius, L. & Sherratt, H. S. A., eds). Portland Press, London, pp. 269-291.

A-72. Meléndez, R., Meléndez-Hevia, E., Mas, F., Mach, J. & Cascante, M. (1998) Physical constraints in the synthesis of glycogen that influence its structural homogeneity. A two-dimensional approach. Biophysical Journal. 75, 106-114.

A-73. Sebert, Ph., Peragón, J., Barroso, J. B., Simon, B. & Meléndez-Hevia, E. (1998) High hydrostatic pressure (101 ATA) changes the metabolic design of yellow freshwater eels. Comparative Biochemistry and Physiology B, 121, 195-200.

A-74. Sebert , P., Peragón, J., Barroso, J. B., Simon, B. & Meléndez-Hevia, E. (1998) Metabolic aclimation of freshwater eels to high pressure: metabolic response times. En: High pressure Biology and Medicine. (Bennett, P. B., Demechenko, I. & Marquis, R. E., eds). University of Rochester Press, Rochester, New York, pp. 237-240.

A-77. Lloréns, M., Nuño, J. C., Rodríguez, Y., Meléndez-Hevia, E. & Montero, F. (1999) Generalization of the theory of transition times in metabolic pathways: A geometrical approach. Biophysical Journal 77, 23-36.

A-78. Heinrich, R., Meléndez-Hevia, E., Montero, F., Nuño, J. C., Stephani, A. & Waddell, T. G. (1999) The structural design of glycolysis: an evolutionary approach. Biochemical Society Transactions 27, 294-298.

A-79. Meléndez, R., Meléndez-Hevia, E. & Canela, E. I. (1999) The fractal structure of glycogen: a clever solution to optimize the cell metabolism. Biophysical Journal 77, 1327-1332.

A-80. Cabezas, H., Raposo, R. R. & Meléndez-Hevia, E. (1999) Activity and metabolic roles of the pentose phosphate cycle in several rat tissues. Molecular and Cellular Biochemistry. 201, 57-63.

A-81. Waddell,T. G., Repovic, P., Meléndez-Hevia, E., Heinrich, R. & Montero, F. (1999) Optimization of glycolysis: new discussions. Biochemical Education 27, 12-13.

A-82. Raposo, R. R., Meléndez-Hevia, E. & Spiro, M. (2000) Autocatalytic formation of colloidal mercury in the redox reaction between Hg2+ and Fe 2+. Journal of Molecular Catalysis. 164, 49-59.

A-83. Meléndez-Hevia, E., Meléndez, R. & Canela, E. I. (2000) Glycogen structure. An evolutionary view. En: Technological and Medical Implications of metabolic control analysis (Cornish-Bowden, A. & Cárdenas, M. L., eds.). Kluwer Scientific Publishers, Dordrecht, pp. 319-326.

A-86. Heinrich, R., Meléndez-Hevia, E., & Cabezas, H. (2002) Optimization of kinetic parameters of enzymes. Biochemistry and Molecular Biology Education 30, 184-188.

A-87. Meléndez-Hevia, E. (2008) Memories of Reinhart Heinrich Journal of Theoretical Biology, 252, 544-545.

A-88. Montero, F., Nuño, J. C., Meléndez-Hevia, E., Olasagasti, F., Vázquez, S. & Morán, F. (2008) Stoichiometric analysis of self-maintaining metabolisms. Journal of Theoretical Biology. Submitted for publication, answering the referees comments Journal of Theoretical Biology. 252, 427-432.

A-89. Meléndez-Hevia, E., Montero-Gómez, N. & Montero, F. (2008) From prebiotic chemistry to cellular metabolism-The chemical evolution of metabolism before Darwinian natural selection. Journal of Theoretical Biology. 252, 505-519.

A-91. Harguindey, S., Orive, G., Cacabelos, R., Meléndez Hevia, E., Díaz de Otazu, R., Arranz, J. L. & Anitua, E. (2008) An integral approach to the etiopathogenesis of human neurodegenerative diseases (HNDDs) and cancer. Possible therapeutic consequences within the frame of the trophic factor withdrawal syndrome (TFWS) Neuropsychiatric Disease and Treatment, 4, 1073–1087.

A-92. Meléndez-Hevia, E. & de Paz-Lugo, P. (2008) Branch-point stoichiometry can generate weak links in metabolism: The case of glycine biosynthesis. Journal of Biosciences, 33, 771-780.

A-93. Meléndez-Morales, D., de Paz-Lugo, P. & Meléndez-Hevia, E. (2009) Glycolysis activity in flight muscles of birds according to their physiological function. An experimental model in vitro to study aerobic and anaerobic glycolysis activity separately. Molecular and Cellular Biochemistry, 328, 127-135.

A-94. Meléndez-Hevia, E. (2009) From the RNA world to modern cells (DNA and proteins). the origin and early evolution of life are found in the ribosome. Journal of Biosciences, 34, 825–827.

A-95. Meléndez-Hevia, E., de Paz-Lugo, P. & Cornish-Bowden, A. & Cárdenas, M. L., (2009) A weak link in metabolism: the metabolic capacity for glycine biosynthesis does not satisfy the need for collagen synthesis. Journal of Biosciences, 34, 853–872.

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18-2-2 Artículos nacionales

Artículos y capítulos de libros en revistas y libros nacionales

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A-1. Meléndez-Hevia, E. (1971) Bases moleculares de la evolución. COL-PA Coloquios de la Cátedra de Paleontología de la Universidad de Madrid, 1, 15-18.

A-5. González de Buitrago, J. M., Meléndez, E. & Municio, A. M. (1975) Microheterogeneidad de las isoenzimas de láctico deshidrogenasa. Revista de la Real Academia de Ciencias (Madrid), número extraordinario dedicado al Prof. Lora Tamayo, pp. 559-588.

A-6. González de Buitrago, J. M., Meléndez, E. & Municio, A. M. (1975) Variaciones de las isoenzimas de láctico deshidrogenasa en cerebro durante el desarrollo. En: Biología perinatal (Botella Llusiá, J. & Municio, A. M., coords). Instituto de España, Madrid, pp. 337-346.

A-18. Meléndez-Hevia, E. (1985) La evolución biológica a través de la historia de la Bioquímica. En: Historia de la Bioquímica (Municio, A. M., coord). Real Academia de Ciencias Exactas, Físicas y Naturales, Madrid, pp. 109-142.

A-21. Meléndez-Hevia, E., Riol-Cimas, J. M. & Torres, N. V. (1987) La teoría del control y su aplicación al metabolismo. Anales de Química, Serie. C, 83, 224-243.

A-36. Meléndez-Hevia, E. (1990) De la láctico deshidrogenasa a la LDH, pasando por el juego de las pentosas y por la teoría del control. En: Bioquímica. Homenaje al Prof. Ángel Martín Municio (Acebal, C., García-Barreno, P., Gavilanes, J. G. & Lizarbe, M. A., coords). Universidad Complutense, Departamento de Bioquímica y Biología Molecular, Madrid, pp. 65-81.

A-37. Meléndez-Hevia, E. (1991) La vía de las pentosas-fosfato. En: Bioquímica, 2ª ed, (Herrera, E., coord). Interamericana/McGraw-Hill, Madrid, pp. 501-528.

A-38. Meléndez-Hevia, E. & Torres, N. V. (1991) Bioquímica teórica. En: Bioquímica, 2ª edic., (Herrera, E., coord). Interamericana/McGraw-Hill, Madrid, pp. 1527-1568.

A-45. Meléndez-Hevia, E. & Montero, F. (1992) Evolución de las rutas metabólicas hacia la simplicidad. El juego del ciclo de las pentosas-fosfato. Revista de la Real Academia de Ciencias Exactas, Físicas y Naturales (Madrid), 86, 369-388.

A-52. Meléndez-Hevia, E. (1995) Evolución y optimización del metabolismo. En: Orígenes de la vida. En el centenario de Aleksandr Ivanovich Oparin (Morán, F., Peretó, J. & Moreno, A., coords). Editorial Complutense, Madrid, pp. 137-187.

A-53. Montero, F., Pérez-Iratxeta, C., Nuño, J. C., Andrade, M. A., Morán, F. & Meléndez-Hevia, E. (1995) Diseño de rutas metabólicas: Optimización del ciclo de las pentosas fosfato. En: Orígenes de la vida En el centenario de Aleksandr Ivanovich Oparin (Morán, F., Peretó, J. & Moreno, A., coords.) Editorial Complutense, Madrid, pp. 189-211.

A-62. Meléndez-Hevia, E. & Cascante, M. (1996) Linus Pauling i els orígens de la Bioquímica Butlletí de les Societats Catalanes de Física, Química, Matemàtiques i Tecnología Núm. especial “Homenatge a Linus Pauling”. Barcelona, Vol. XVI, pp. 95-106.

A-69. Meléndez-Hevia, E., Raposo, R. R., Meléndez, R. & Cabezas, H. (1997) Revisión de los métodos filogenéticos de secuencias: una crítica a la teoría de Kimura sobre el neutralismo de la evolución molecular. Revista de la Academia Canaria de Ciencias, 9, 65-86.

A-75. Meléndez-Hevia, E. (1998) Paleometabolismo. En: Paleontología 3ª edic. (Meléndez, B., coord), CSIC, Madrid., pp. 243-269.

A-76. Meléndez, B. & Meléndez-Hevia, E. (1998) Paleoespecies. En: Paleontología, 3ª edic. (Meléndez, B., coord). CSIC, Madrid, pp. 436-437.

A-84. Meléndez-Hevia, E. (2000) La lógica matemática de la célula viva. En: Matemáticas 2000 (número especial de la revista Números, vols. 43 y 44), editado con motivo del año mundial de las Matemáticas (Méndez, J. M. y Martinón, A., eds). Tenerife.

A-85. Meléndez-Hevia, E. (2000) La lógica matemática de la célula viva. En: Las Matemáticas del siglo XX. Una mirada en 101 artículos (Martinón, A., ed). Nivola Libros y Ediciones, S. L., Madrid.

A-90. Hargindey, S., Orive, G., Anitua, E., Arranz, J. L., Cacabelos, R., Díaz de Otazu, R. & Meléndez Hevia, E. (2008) Hacia un Nuevo enfoque de las enfermedades neurodegenerativas. GenT – The EuroEspes Journal, Junio, No 3, 82-89.

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