18-4-1 Congresos internacionales

Curriculum del Prof. Meléndez-Hevia

Comunicaciones presentadas en congresos internacionales

C-3. Meléndez-Hevia, E., Corzo, J. & Pérez, J. A. Electrophoretic patterns of pyruvate kinase isoenzymes. Electrophoresis’81. 3rdc International Conference on Electrophoresis. Charleston, South Carolina, USA, Abril 1981.

C-4. Betancor, P. de Armas, A., Meléndez-Hevia, E. & González-Lama, Z. Isoenzymes of peroxide dismutase in liver from Lacerta stehlini. Electrophoresis’81. 3rd International Conference on Electrophoresis. Charleston, South Carolina, USA, Abril, 1981.

C-5. González-Lama, Z., Cutillas, M. J., Lamas, A. M. & Meléndez-Hevia, E. Polyacrylamide-starch gel electrofocusing of catalase from Pseudomonas aeruginosa. Electrophoresis’82. 4th International Conference on Electrophoresis. Atenas, Grecia, Abril 1982.

C-15. Montero, F., Morán, F., García-Tejedor, A., Riol-Cimas, J. M. & Meléndez-Hevia, E. Influence of the transition state of the glycolysis lower-part on the phosphofructokinase oscillations. II International Conference on Biothermodynamics. Seggau, Austria, 8-13 Septiembre 1985.

C-17. Meléndez-Hevia, E. Determination of flux control coefficients by shortening and enzyme-titration of metabolic pathways. Advanced Research Workshop on Control of Metabolic Processes. Il Ciocco (Lucca), Italia. 9-15 Abril 1989.

C-18. Meléndez-Hevia, E., Torres, N. V. & Montero, F. The game of the pentose phosphate cycle: a mathematical approach to study the economy of design in metabolic pathways. NATO Advanced Research Workshop on Control of Metabolic Processes. Il Ciocco (Lucca), Italia, 9-15 Abril 1989.

C-19. Torres, N. V., Meléndez-Hevia, E. & Sicilia, J. Control theory at high enzyme concentrations. NATO Advanced Research Workshop on Control of Metabolic Processes. Il Ciocco (Lucca), Italia, 9-15 Abril 1989.

C-22. Torres, N. V., Meléndez-Hevia, E., Sicilia, J. & Kacser, H. Control analysis of transition times in metabolic systems. International Symposium on Mathematical models of cellular processes. Holzhau, República Democrática Alemana, Noviembre 1989.

C-23. Meléndez-Hevia, E. The game of the pentose phosphate cycle: a mathematical approach to study the evolution and design of metabolic pathways. International Symposium on Mathematical Models of Cellular Processes. Holzhau, (Dresden), República Democrática de Alemania (GDR), 19-23 Noviembre 1989.

C-24. Meléndez-Hevia, E. & Montero, F. Optimization of metabolism: the evolution of metabolic pathways through the game of the pentose phosphate cycle. Biothermokinetics Conference. Noordwijkerhout, Holanda, 31 Agosto – 2 Septiembre 1990.

C-25. Kacser, H., Acerenza, L., Sauro, H. M . & Meléndez-Hevia, E. The time-dimension in Control Analysis. Biothermokinetics Conference. Noordwijkerhout, Holanda, 31 Agosto – 2 Septiembre 1990.

C-28. Meléndez-Hevia, E. Waddell, T. G., & Montero, F. Selection of enzymatic mechanisms which account for simplicity in the evolution of metabolic pathways. First World Congress of Nonlinear Analysts. Tampa, Florida, USA, 19-26 Agosto 1992.

C-29. Meléndez-Hevia, E. & Waddell, T. G. & Sicilia, J. Optimization of the glycogen design in the evolution of metabolism. 2nd Gauss Symposium. Biomedical Physics sessions. Munich, (Alemania), 2-7 Agosto, 1993.

C-30. Montero, F., Nuño, J. C., Andrade, M. A., Morán, F. & Meléndez-Hevia, E. The role of natural selection and evolution in the game of the pentose phosphate cycle. 2nd Gauss Symposium. Sessions on Biomedical Physics. München (Alemania), 2-7 Agosto 1993.

C-31. Meléndez-Hevia, E. Evolution of metabolism: optimization of glycogen structure. 2nd European Conference on Mathematics applied to Biology and Medicine. Lyon (Francia), 15-18 Diciembre, 1993.

C-32. Meléndez-Hevia, E. Physiological optimization of metabolism. An evolutionary approach (Plenary session). 1st Meeting of Mediterranean physiologists/XXVI Congress of the Spanish Society of Physiological Sciences. Palma de Mallorca. (Chairman: R. Rial)., 4-9 Abril, 1994.

C-33. Raposo, R. R., Boluda, C., Cabezas, H. & Meléndez-Hevia, E. Phosphate cycle in rat tissues. A new method for assaying the whole pathway activity. 1st meeting of Mediterranean Physiologists. Palma de Mallorca, 4-8 Abril 1994.

C-34. Meléndez-Hevia, E. Evolution and optimization of metabolism. International Symposium on Integrative Biochemistry (3rd. Int S-Systems Symposium). Barcelona, 26-29 Junio, 1994.

C-35. Cabezas, H., Boluda, C., Reyes, J., Raposo, R. R. & Meléndez-Hevia, E. Pentose phosphate cycle in rat tissues. Activity of the whole pathway, and assay of each phase separately. International Symposium on Integrative Biochemistry (3rd. Int S-Systems Symposium). Barcelona, 26-29 Junio, 1994.

C-36. Boluda, C., Cabezas, H. & Meléndez-Hevia, E. Metabolite. A computer software package to study metabolic design and regulation. International Symposium on Integrative Biochemistry (3rd. Int S-Systems Symposium). Barcelona, 26-29 Junio, 1994.

C-37. Meléndez-Hevia, E. Optimization of glycolysis.-Chemical analysis. Workshop on evolution of metabolism. Granada, 9-14 Septiembre, 1994.

C-38. Meléndez-Hevia, E. Theoretical approaches to the evolutionary optimization of glycolysis.-Chemical analysis. Workshop on Evolution and Optimization of Metabolism. Barcelona, 27 Febrero -2 Marzo, 1995.

C-39. Meléndez, R., Meléndez-Hevia, E., Montero, F. & Cascante, M. Evolutionary significance of the role of carbonic anhydrase in biomineralization processes. Workshop on Evolution and Optimization of Cellular Processes. Barcelona, 27 Febrero – 2 Marzo, 1995.

C-40. Montero, F., Nuño, J. C., Andrade, M. A., Pérez Iratxeta, C., Morán, F. & Meléndez-Hevia, E. The role of natural selection and evolution in the game of the pentose phosphate cycle. International Symposium on Integrative Biochemistry (3rd. International S-Systems Symposium). Barcelona, 27 Febrero – 2 Marzo, 1995.

C-41. Puigjaner, J., de Atauri, P., Meléndez-Hevia, E., Lee, P. & Cascante, M. A new experimental approach to investigate the pentose cycle design, with 13C-substrates. Workshop on Evolution and Optimization of Cellular Processes. Barcelona, 27 Febrero – 2 Marzo, 1995.

C-42. Meléndez-Hevia, E. Theoretical approaches to the evolutionary optimization of glycolysis: Chemical analysis. Workshop on Design and Evolution of Metabolism. Puerto de la Cruz, Tenerife, 20-23 Septiembre, 1995.

C-43. Meléndez, R., Valero, R., Waddell, T. G., Meléndez-Hevia, E., & Cascante, M. The eye problem in glycogen structure: What is the use of a half glycogen? International Workshop on Design and Evolution of Metabolism. Puerto de la Cruz, Tenerife, 20-23 Septiembre, 1995.

C-44. Raposo, R. R., Cascante, M. & Meléndez-Hevia, E. Method to assay enzyme activity at unfavourable thermodynamic conditions. Application to lactate dehydrogenase in lactate-pyruvate direction. International Workshop on Design and Evolution of Metabolism. Puerto de la Cruz, Tenerife, 20-23 Septiembre, 1995.

C-45. Sicilia, J., Cabezas, H., Cascante, M. & Meléndez-Hevia, E. Towards a theory for metabolic response time: t99 and its control. International Workshop on Design and Evolution of Metabolism. Puerto de la Cruz, Tenerife, 20-23 Septiembre, 1995.

C-46. Garrido, M., Puigjaner, J., Reyes, J. A., Cascante, M. & Meléndez-Hevia, E. Metabolic response time in anaerobic glycolysis. Activity in pectoral muscle of hen assayed by a lactate electrode. International Workshop on Design and Evolution of Metabolism. Puerto de la Cruz, Tenerife, 20-23 Septiembre, 1995.

C-47. Boluda, C., Cabezas, H. & Meléndez-Hevia, E. Metabolite 2.3. A computer tool to study kinetic design of metabolism. International Workshop on Design and Evolution of Metabolism. Puerto de la Cruz, Tenerife, 20-23 Septiembre, 1995.

C-48. Kholodenko, B. N., Westerhoff, H. V., Meléndez-Hevia, E. & Cascante, M. Evolutionary consequences of metabolic channelling: can the concentrations of free intermediates and the transition time in a pathway decrease? International Workshop on Design and Evolution of Metabolism. Puerto de la Cruz, Tenerife, 20-23 Septiembre, 1995.

C-49. Comín, B., Puigjaner, J., Lupiáñez, J. A., Meléndez-Hevia, E. & Cascante, M. Optimization of metabolism. Molecular mechanisms of production and recycling of lactate in animals. International Workshop on Design and Evolution of Metabolism. Puerto de la Cruz, Tenerife, 20-23 Septiembre, 1995.

C-50. Centelles, J. J., Meléndez-Hevia, E. & Cascante, M. A model for the urea cycle in rat liver cells. I Portuguese-Spanish Biophysics Congress/ V Congress of Spanish Society of Biophysics. Lisboa, Portugal, 4-7 Diciembre, 1995.

C-51. Meléndez-Hevia, E. Chemical possibilities for glycolysis design and the solution found in metabolic evolution. Workshop on Theoretical Biophysics Berlin (Alemania) 5-6 Diciembre, 1995.

C-52. Meléndez, R., Meléndez-Hevia, E., Waddell, T. G. & Cascante, M. Further results in optimization of glycogen structure: Relationships among the branching degree, the number of tiers, and the chain length. Workshop on Theoretical Biophysics. Berlin (Alemania) 5-6 Diciembre, 1995.

C-53. Meléndez-Hevia, E. Experimental methods for analysing control, and their application to the study of glycolysis and gluconeogenesis. FEBS’96 24th Meeting – Federation of European Biochemical Societies, Workshop on Metabolic control analysis. Barcelona, 7-12 Julio 1996.

C-54. Meléndez-Hevia, E. Optimization of glycogen: Evolution and Paleometabolism. Workshop on Theoretical Biophysics Hiddensee (Alemania), 1-3 Abril, 1998.

C-55. Meléndez, R., Meléndez-Hevia, E. & Canela, E. I. The fractal properties of glycogen. Workshop on Theoretical Biophysics. Hiddensee (Alemania), 1-3 Abril, 1998.

C-56. Cabezas, H., Lloréns, M., Nuño, J. C., Montero, F. & Meléndez-Hevia, E. Metabolic response time. Some theoretical aspects, and experimental data. Workshop on Theoretical Biophysics. Hiddensee (Alemania), 1-3 Abril, 1998.

C-57. Garrido, M., Lloréns, M., Nuño, J. C., Montero, F. & Meléndez-Hevia, E. Transition times in glycolysis: an experimental system based on lactate assay. Workshop on Theoretical Biophysics. Hiddensee (Alemania), 1-3 Abril, 1998.

C-58. Meléndez-Hevia, E. Problemas de solubilidad en el citoplasma celular. 3rd Colloquium on Solution Chemistry La Laguna, Tenerife, Abril, 1998.

C-59. Meléndez, R., Canela, E. I. & Meléndez-Hevia, E. The fractal structure of glycogen. A clever solution for optimizing the molecular structure. 2nd Portuguese-Spanish Biophysics Congress. Madrid, 4-7 Diciembre, 1998.

C-60. Meléndez-Hevia, E. Glucogen structure: a model of evolution and optimization of molecular design. Workshop on Biophysics of the Cellular Function. 2nd Portuguese-Spanish Biophysics Congress. Madrid, 4-7 Diciembre, 1998.

C-61. Meléndez-Hevia, E. Glycogen structure: an evolutionary view. Workshop on Technological and Implications of Metabolic Control Analysis. Visegrad (Hungría), 10-16 Abril, 1999.

C-64. Meléndez-Hevia, E., Meléndez, R. & Canela, E. I. Glycogen biosynthesis: a case for a general theory of metabolic regulation. NATO Advanced Research Workshop on Technological and Medical Implications of Metabolic Control Analysis. Visegrad (Hungary), 10-16 Abril, 1999.

C-65. Montero, F., Lloréns, M., Nuño, J.C., Rodríguez, Y. & Meléndez-Hevia, E. The problem of the response time: a general solution. NATO Advanced Research Workshop on Technological and Medical Implications of Metabolic Control Analysis. Visegrad (Hungary), 10-16 Abril, 1999.

C-69. Meléndez-Hevia, E. & Meléndez, R. Optimization of glycogen: Molecular design, metabolism, and fractal structure VI International Symposium on Biochemical Systems Theory (Symbiosys). Puerto de la Cruz, Tenerife, 25-29 Septiembre, 2000.

C-70. Heinrich, R., Cabezas, H. & Meléndez-Hevia, E. Optimization of enzyme kinetics: a simple case to show the optimization function in a two-step mechanism. VI International Symposium on Biochemical Systems Theory (Symbiosys). Puerto de la Cruz, Tenerife, Septiembre 25-29, 2000.

C-71. Meléndez, D. & Meléndez-Hevia, E. Paleometabolism: A poorly optimized pentose phosphate cycle in Echinoderm paleospecies from Jurassic (150 Million years ago). Characterization of an odd transketolase (TK1) which transfers a C1 unit between aldo-sugars. VI International Symposium on Biochemical Systems Theory (Symbiosys). Puerto de la Cruz, Tenerife, 25-29 Septiembre, 2000.

C-78. Meléndez-Hevia, E. Natural selection, thermodynamics and optimisation of metabolic design. Workshop Theoretical Biophysics 2003/ Graduate Program “Dynamics and Evolution of Cellular and Macromolecular Processes”, Hiddensee (Alemania), 2-5 Abril, 2003.

C-79. Meléndez Morales, D. & Meléndez-Hevia, E. Football and glycolysis design. Workshop Theoretical Biophysics. Hiddensee (Alemania), 2-5 Abril, 2003.

C-80. de Paz, P., Meléndez, D. & Meléndez-Hevia, E. Fish swimming habits and muscle metabolic design. Workshop Theoretical Biophysics 2003, Hiddensee (Alemania), 2-5 Abril, 2003.

C-87. de Paz, P., Meléndez Morales, D. & Meléndez-Hevia, E. An experimental model to study arthrosis and physical injuries: stimulation of collagen biosynthesis in mouse fibroblasts cultured in vitro with essential amino acids. 3rd Portuguese-Spanish Biophysics Congress. Lisboa, 29 Octubre – 1 Noviembre 2004.

C-88. Pardo, M. R., Meléndez-Morales, D. & Meléndez Hevia, E. Krebs cycle activity in red-fibres skeletal-muscle mitochondria: a method that allows to quantify the role of a given compound as substrate or feeder. 3rd Portuguese-Spanish Biophysics Congreso / IX Congreso Hispano-Luso de Biofísica.. Lisboa, October 29 – November 1, 2004.

C-89. Meléndez, D. & Meléndez-Hevia E. Muscle Physiology and Metabolism: Constitutive characteristics and endurance training adaptation. XXIII Congress of The Spanish Society of Physiological Sciences, Sevilla, 10-13 Febrero 2005. Abstract publicado en J. Physiol. Biochem., 61, 288 (2005).

C-91. Meléndez-Hevia, E. The conflict of public science versus protection of industrial property and intellectual rights. Final EPIP Conference European Policy For Intellectual Property: “Towards the European Network of Excellence on Intellectual Property and the Knowledge Economy” Santiago de Compostela, 6-8 Octubre 2005.

C-93. de Paz Lugo, P., Meléndez-Morales, D. & Meléndez-Hevia, E. Effect of amino acids added to the culture medium on collagen biosynthesis by chondrocytes cultured in vitro. 10th World Congress on Osteoarthritis. Ostearthritis Research Society International (OARSI). Boston, Mass (USA). 8-11 Diciembre 2005.

C-100. Meléndez-Hevia, E., de Paz-Lugo, P., Meléndez-Morales, D. & Montero, F. The theory of the weak links in metabolism. Glycine is an essential amino acid in humans. VI Ibero-American Congress of Biophysics. Madrid, 24-26 Septiembre 2006.

C-101. Meléndez-Hevia, E., de Paz-Lugo, P., Meléndez-Morales, D. & Montero, F. (2006) Nutritional need of glycine in humans as a consequence of a weak point of metabolism in glycine synthesis pathway. VI Ibero-American Congress of Biophysics. Madrid, 24-26 Septiembre 2006.

C-102. Pardo, M. R., Meléndez-Morales, D., Montero, F., & Meléndez-Hevia, E. Uncoupling effect of succinate on oxidative phosphorylation allows Krebs’ cycle to work without dependence on ATP synthesis. VI Ibero-American Congress of Biophysics. Madrid, 24-26 Septiembre, 2006.

C-103. Montero-Gómez, N., Montero, F. & Meléndez-Hevia, E. Origin and evolutionary optimization of Calvin’s cycle in photosynthesis. A paradigmatic case of how biological evolution has worked at the molecular level VI Ibero-American Congress of Biophysics. Madrid, 24-26 Septiembre 2006.

C-105. Meléndez-Hevia, E., Meléndez Morales, D., de Paz Lugo, P., Pardo, M. R & Montero Gómez, N. The weak points in metabolism: causes consequences in the emergence of degenerative diseases, and its treatment by means of nutritional supplements. II International Symposium on Biochemistry and Molecular Biology. — 27th Latin American Congress on Chemistry. – 6th International Congress on Chemistry and Chemical Engineering. La Habana, Cuba, 16-20 Octubre 2006.

C-106. Meléndez-Hevia, E. A new way of teaching Biochemistry based on the knowledge of the chemical and mathematical logic of metabolism. II International Symposium on Biochemistry and Molecular Biology. — 27th Latin American Congress on Chemistry. – 6th International Congress on Chemistry and Chemical Engineering. La Habana, Cuba, 16-20 Octubre 2006.

C-108. Meléndez-Hevia, E. The theory of the weak points in metabolism – The glycine synthesis pathway and its problems. Symposium on Systems Biology – Sociedad de Biofísica de España. Madrid, 6-8 Junio 2007.

C-112. de Paz-Lugo, P. & Meléndez-Hevia, E., Effect of amino acid diet supplementation on body mechanical structure. XXXIV Congress of the Spanish Society for Physiological Sciences (SECF) in collaboration with the Spanish Physiological Society. Valladolid, 3-7 Julio 2007. Abstract publicado en Acta Physiologica, 190, Suppl. 655, 111 (2007).

C-114. Martín Santiago, M. P., Meléndez-Hevia, E., Rosell i Juvilla, R., de Paz-Lugo, P. Stimulation of collagen in oral area. IXth SELO Congress (Spanish Society of Laser Odontology): Odontology in the XXIth Century: Laser technology. Salamanca, 28-29 Noviembre 2008.

C-115. De Paz-Lugo, P., Vázquez, S., González, V., Meléndez-Hevia, E., Piedrafita, G., Xavier, D., Morán, F. & Montero, F. (2008) Stoichiometric analysis: applications ? Origin and evolution of metabolism. 4th Meeting of the Spanish Systems Biology Network (REBS): From genomes to in silico and back. Valencia. 1-2 Diciembre 2008.

C-116. Meléndez-Hevia, E. Natural Selection and pH in the development of cancer. International Symposium on Proton transport and its inhibition (PTI) in the etio-pathogenesis, diagnosis and treatment of cancer – Ramón Areces Foundation. Madrid, 28-29 Abril 2009.

C-117. Cárdenas, M. L., Meléndez-Hevia, E., de Paz-Lugo, P. & Cornish-Bowden, A. A weak link in metabolism: humans cannot synthesize enough glycine to meet metabolic requirements. 34th FEBS Congress on Life’s molecular interactions, Praga (Czech Republic), 4-8 Julio 2009.

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